Alex Dimitriu, MD

Menlo Park Psychiatry & Sleep Medicine

PUBLICATIONS:

I have had the honor of working with several leading experts in the fields of psychiatry and sleep medicine - below is a summary of some of my work.


Encyclopedia of Sleep Medicine - Hypersomnia - Etiologies 
http://www.sciencedirect.com/science/article/pii/B9780123786104002163
There are several types of hypersomnia, having many causes, some still unknown. They can be subdivided into chronic or recurrent. The chronic hypersomnias can be caused by a variety of medical and/or psychiatric conditions, in addition to disorders disruptive of sleep, including obstructive sleep apnea, upper airway resistance syndrome, periodic limb movements, and restless leg syndrome. Once the known causes of hypersomnia have been exhausted, the diagnosis of idiopathic hypersomnia can be made. It is a challenging diagnosis and little is known of its etiology. 2013, Pgs  377–382


Preface Sleep Medicine- A challenging field with many new findings
Med Clin North Am. 2010 May;94(3):xi-xiv. Dimitriu A, Guilleminault C.
Source Division of Sleep Medicine, Stanford University School of Medicine, Stanford Medical Outpatient Center, 450 Broadway Street, Pavilion C, Redwood City, CA 94063-5074, USA.


Expert Opinion - Pharmacotherapy of Narcolepsy
 2010 Jul;11(10):1633-45. Expert opinion on pharmacotherapy of narcolepsy. Zaharna M, Dimitriu A, Guilleminault C. Source Stanford Medical Outpatient Center, Sleep Medicine Division MC 5704, Stanford University, Redwood City, Stanford, CA 94063, USA.

Narcolepsy is a neurodegenerative disorder resulting in the instability of the sleep-wake cycle and marked by low levels of hypocretin in cerebrospinal fluid. Sleep instability is marked by brisk, sleep-onset REM periods and sleep fragmentation, while the waking state is interrupted by the intrusion of REM sleep and sometimes accompanied by cataplectic attacks. Current pharmacologic interventions that aim to address three primary features of this disorder; excessive daytime sleepiness (EDS), cataplexy and automatic behaviors, and sleep fragmentation. We review and compare the use of traditional and new stimulants in the treatment of EDS. For the treatment of cataplexy and automatic behaviors, serotonergic and noradrenergic agents are considered. The role of gamma-hydroxybutyrate (GHB) is also explored in its ability to reduce daytime sleepiness and cataplectic attacks and to consolidate sleep. Findings are based on a PubMed literature search of clinical and basic science research papers spanning 1977-2009.

A comprehensive understanding of the various existing and promising future treatments for narcolepsy. For each of these treatments, we evaluate risks versus benefits of treatment, and proposed pharmacologic mechanisms of action. We conclude with a review of new treatment approaches, including thyrotropin-releasing hormone (TRH), histamine agonists, immunotherapy and hypocretin replacement therapies.Narcolepsy is an autoimmune, neurodegenerative disorder that results in significant sleep-wake instability with or without cataplectic attacks. Current treatments aim symptomatically to reconsolidate the sleep and waking states and to reduce daytime attacks of cataplexy. Future treatments aim primarily towards correcting the causal deficiency of hypocretin or preventing the autoimmune response that results in the loss of hypocretin cells.


ARTICLES:

NBC News - Sexsomniacs put the moves on without waking

http://bodyodd.nbcnews.com/_news/2010/06/07/4464502-sexsomniacs-put-the-moves-on-without-waking

Guest Blogger - European Sleep Works (sleepworks.com) Sleep, CBTi, and Following your Grandma's Advice

http://www.sleepworks.com/blog/2014/02/05/guest-blogger-dr-alex-dimitriu-discusses-sleep-cbti-and-following-your-grandmothers-advice/

MENLO PARK  PSYCHIATRY & SLEEP MEDICINE  650-326-5888

CONDITIONS TREATED: anxiety, depression, attention deficit disorder, insomnia, bipolar disorder, and treatment resistant depression.

REGIONS COVERED:  We serve clients of the Bay Area, including the communities of Menlo Park, Palo Alto, Cupertino, Los Gatos, Los Altos, Mountain View, Portola Valley, Atherton, Sunnyvale, and San Jose